Digitally Ventilated Cages ISO Mice



Available in

  • Overview
  • Scientific
  • Downloads
  • Video

Tecniplast ISOCAGE N and ISOCAGE P systems for biocontainment and bioexclusion, respectively, are boosted by the DVC® capabilities to provide novel insights and enhance animal welfare checks thanks to the automatic data collection directly from the cage level. Specifically designed DVC® board can be easily retrofitted to already existing ISOCAGE P/N systems and enable different benefits for the researchers and vivarium people.

Main benefits are:

  • Evaluate bedding condition for standardizing cage conditions, reducing running costs and avoid unnecessary animal handlings

  • 24/7 Detect spontaneous locomotion for a complete and automatic continuous animal welfare check

  • 24/7 Prevent any loss due to unexpected water floods

  • Streamline and balance Facility workload: DVC® allows to customize the system according to your needs and SOPs and automatically balance your Vivarium workload to reach its maximum efficiency

  • Real time cage tracking system: DVC® features an automatic cage tracking system that in real time collects these data for you: all the information you need for billing purposes are just one click away!

  • Used in conjunction with the DVC® Analytics, remotely evaluate animal activity data that can be used to asses animal welfare reducing physical manual checks

  • Used in conjunction with the DVC® Analytics, complement your studies with novel insights coming from a 24/7 data collection approach.

The Digital Ventilated Cage (DVC®) documents animal activity at the home cage level throughout your study and supports surveillance of your animals. 

DVC monitors the animal activity in the home cage. By means of a sensor plate the system’s software captures data 24/7 and compares it to different days and similar cages. 

With DVC you can document the level of activity in any cage on the IVC rack throughout your study. Peaks of high or low activity are detected and indicate which cages you should pay special attention to during the daily inspection. This helps you detect animals that may need special care, ensures that humane endpoints are met early and that you do not loose valuable data.

“By using continuous home-cage recordings we observed that food and water restriction induced a reversible reduction of overall activity levels that went undetected using the instantaneous scoring method.” (Goltstein et al. 2018).

“DVC is effective in identifying mouse cages with patterns of high activity levels, signaling possible aggression incidences, thus potentially allowing for early intervention and consequently improving animal welfare.” (Giles et al. 2018).

“The system detected an increase in activity preceding and peaking around lights-on followed by a decrease to a rest pattern. At lights off, activity increased substantially displaying a distinct temporal variation across this period. We also documented impact on mouse activity that standard animal handling procedures have, e.g. cage-changes, and show that such procedures are stressors impacting in-cage activity. These key observations replicated across the three test-sites… These data demonstrate that home cage monitoring is scalable and run in real time, providing complementary information for animal welfare measures, experimental design and phenotype characterization. (Pernold et al. 2019).

“The results show that the proposed home-cage monitoring system can provide animal activity metrics that are comparable to the ones derived via a conventional video tracking system, with the advantage of system scalability, limited amount of both data generated, and computational capabilities required to derive metrics.” (Iannello F. 2018).

”In summary, our results indicate that, for the measures recorded, there was no significant impact on the behaviour and welfare of low frequency EMF exposure experienced continuously over a six-week period as an integrated part of this IVC housing system for BALB/cAnNCrl and C57BL/6NCrl mice.” (Burman et al. 2018).


Goltstein, PM et al 2018: Food and water restriction lead to differential learning behaviors in a head-fixed two-choice visual discrimination task for mice. PLoS ONE 13 (9): 1-19

Giles, JM et al 2018: Effect of Environmental Enrichment on Aggression in BALB/cJ and BALB/cByJ Mice Monitored by Using an Automated System. JAALAS 57 (3): 236-243

Pernold, K et al 2019: Towards large scale automated cage monitoring – Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique. PLoS ONE 14 (2): 1-20

Iannello, F 2018: Non-intrusive high throughput automated data collection from the home cage. Heliyon 5: e01454

Burman, O et al 2018: The effect of exposure to low frequency electromagnetic fields (EMF) as an integral part of the housing system on anxiety-related behaviour, cognition and welfare in two strains of laboratory mouse. PLoS ONE 13 (5): e0197054

Additional reading:

Automated Mouse Cages Help Reveal Subtle Disease Signs - Produced by Nature Research & Tecniplast

Electromagnetic fields (EMF) – Clearing up a natural phenomena

Home-Cage Monitoring and Its Effects on Research Capability and Outcomes - An Expert Panel Discussion

Recordati, C et al 2019: Long-Term Study on the Effects of Housing C57BL/6NCRL Mice in Cages Equipped with Wireless Technology Generating Extremely Low-Intensity Electromagnetic Fields. Toxicologic Pathology: https://doi.org/10.1177/0192623319852353 

Technology that remotely tracks mouse cages can reduce animal stress and reveal environmental factors that undermine the reliability of experimental data. Experiences from leading universities

DVC® introduction

DVC® tutorials