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Digitally Ventilated Cages Mice

DVC LITE

Tecniplast

Available
DK, SE, NO & FI

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DVC® Lite has been designed for all the users who want to achieve the best performances regarding Vivarium cage management. DVC® Lite is a lighter but still extremely powerful version of the DVC® system that offers a fundamental subset of the full benefits offered by the DVC®system itself. Moreover, this is the specific solution available also for all the 2GM Tecniplast customers who cannot physically retrofit the entire DVC® system into their original previous release of Tecniplast IVC Racks.

Benefits are:

  • Real time cage tracking system: DVC® Lite features an automatic cage tracking system that in real time collects these data for you: all the information you need for billing purposes are just one click away!
  • (STATISTICALLY) STREAMLINE YOUR JOB- The DVC® Lite system suggests when cage change needs to be performed based on statistical evaluation performed on a number of animals in every cage. This statistically driven suggestion standardizes cages condition and reduces animals stress, the number of cage changes as well as ergonomic issues related to repetitive actions, while cutting running costs and autoclave cycles
  • 24/7 Prevent any loss due to unexpected water floods coming from AWS

The Digital Ventilated Cage (DVC®) documents animal activity at the home cage level throughout your study and supports surveillance of your animals. 

DVC monitors the animal activity in the home cage. By means of a sensor plate the system’s software captures data 24/7 and compares it to different days and similar cages. 

With DVC you can document the level of activity in any cage on the IVC rack throughout your study. Peaks of high or low activity are detected and indicate which cages you should pay special attention to during the daily inspection. This helps you detect animals that may need special care, ensures that humane endpoints are met early and that you do not loose valuable data.

“By using continuous home-cage recordings we observed that food and water restriction induced a reversible reduction of overall activity levels that went undetected using the instantaneous scoring method.” (Goltstein et al. 2018).

“DVC is effective in identifying mouse cages with patterns of high activity levels, signaling possible aggression incidences, thus potentially allowing for early intervention and consequently improving animal welfare.” (Giles et al. 2018).

“The system detected an increase in activity preceding and peaking around lights-on followed by a decrease to a rest pattern. At lights off, activity increased substantially displaying a distinct temporal variation across this period. We also documented impact on mouse activity that standard animal handling procedures have, e.g. cage-changes, and show that such procedures are stressors impacting in-cage activity. These key observations replicated across the three test-sites… These data demonstrate that home cage monitoring is scalable and run in real time, providing complementary information for animal welfare measures, experimental design and phenotype characterization. (Pernold et al. 2019).

“The results show that the proposed home-cage monitoring system can provide animal activity metrics that are comparable to the ones derived via a conventional video tracking system, with the advantage of system scalability, limited amount of both data generated, and computational capabilities required to derive metrics.” (Iannello F. 2018).

”In summary, our results indicate that, for the measures recorded, there was no significant impact on the behaviour and welfare of low frequency EMF exposure experienced continuously over a six-week period as an integrated part of this IVC housing system for BALB/cAnNCrl and C57BL/6NCrl mice.” (Burman et al. 2018).

References:

Goltstein, PM et al 2018: Food and water restriction lead to differential learning behaviors in a head-fixed two-choice visual discrimination task for mice. PLoS ONE 13 (9): 1-19

Giles, JM et al 2018: Effect of Environmental Enrichment on Aggression in BALB/cJ and BALB/cByJ Mice Monitored by Using an Automated System. JAALAS 57 (3): 236-243

Pernold, K et al 2019: Towards large scale automated cage monitoring – Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique. PLoS ONE 14 (2): 1-20

Iannello, F 2018: Non-intrusive high throughput automated data collection from the home cage. Heliyon 5: e01454

Burman, O et al 2018: The effect of exposure to low frequency electromagnetic fields (EMF) as an integral part of the housing system on anxiety-related behaviour, cognition and welfare in two strains of laboratory mouse. PLoS ONE 13 (5): e0197054

Additional reading:

Electromagnetic fields (EMF) – Clearing up a natural phenomena

Home-Cage Monitoring and Its Effects on Research Capability and Outcomes - An Expert Panel Discussion

Recordati, C et al 2019: Long-Term Study on the Effects of Housing C57BL/6NCRL Mice in Cages Equipped with Wireless Technology Generating Extremely Low-Intensity Electromagnetic Fields. Toxicologic Pathology: https://doi.org/10.1177/0192623319852353 

Technology that remotely tracks mouse cages can reduce animal stress and reveal environmental factors that undermine the reliability of experimental data. Experiences from leading universities